Inspired by

the wonders of

groundbreaking

Swiss ultraﬁltration

technology MF Plus

introduces

Nano Organo Peptides

modern tissue rejuvenating therapy with

powerful bioactive molecules, nutrients and

peptides for the great health of your skin

Mito Organelles

the groundbreaking innovation in organ

speciﬁc peptide therapy – fusion of traditional

cell therapy and mitochondrial medicine

Understanding Skin Aging Process

Aging of the skin is an inevitable part of the aging process. Age-related changes in the skin

are the results of intrinsic factors, such as genetics, lifestyle, personal habits and a continuous

environmental damage, predominantly due to ultraviolet radiation, which is responsible for

skin’s photo-aging, as well as toxins and heavy metals that are causing a damage to the skin.

The facial aging is associated with facial skin volume loss, reduction of the elasticity, moistness

and thickness, appearance of wrinkles and folds, pigmented spots, lentigos, and keratosis.

Histological changes include thinning of epidermis, attening of epidermal-dermal interface,

reduction and disorganization of collagen and elastin, slowdown of cell turnover, reduction of

melanocytes erratic melanocytic activity and the phenomenon of solar elastosis.

(Fisher GJ, Kang S, Varani J, et al. Mechanisms of photoaging and chronological skin aging. Arch. Dermatol. 2002;138: 1462–70.

Peres PS, Terra VA, Guarnier FA, Cecchini R, Cecchini AL. Photoaging and chronological aging prole: Understanding oxidation of the skin. J

Photochem Photobiol B. 2011;103(2):93–97.

Sjerobabski Masnec I, Poduje S. Photoaging. Coll. Antropol. 2008;32:177–80.

West MD. The cellular and molecular biology of skin aging. Arch Dermatol. 1994;130:87–95).

Synergistic Eect for Natural Regeneration

and Biorevitalization of the Skin.

Apart from the internal organic and systemic rejuvenation, facial revitalization is an essential part

of holistic rejuvenation. The ultimate goal of facial revitalization and rejuvenation is restoration

and maintenance of healthy and young-looking skin. The obtained eects include improvements

of skin elasticity, rmness, hydration, and pigmentation and are achieved by injection into the

supercial dermis of biocompatible and absorbable products. A number of clinical studies has

proven that main goal of the mesotherapy products are promoting the broblast activation,

stimulation of collagen and tropoelastin biosynthesis and increase of cell turnover.

(Iorizzo M, De Padova MP, Tosti A. Biorejuvenation: theory and practice. Clin Dermatol. 2008; 26:177–181

Tosti A, De Padova MP. Atlas of Mesotherapy in Skin Rejuvenation. London: Informa Healthcare; 2007

Galadari H, Al Faresi F. Mesotherapy. Skinmed 2011;9:342–3)

•

Natural biological anti – aging system for skin at any age

•

Approved treatment protocol

•

No known side eects

•

Additive free

•

Sterile

•

Low molecular weight for fast absorption and excellent tissue integration

•

Stability and total control throughout the treatment

Considered highly for their natural restorative function, aesthetic range of Nano Organo

Peptides and Mito Organelles currently comprise of few types of outstanding ingredients: skin,

mesenchyme, placental peptides (or in addition with collagen and elastin).

Mesenchyme (NOP and MO) – stretch marks, sagging skin, distinct eye bags, ne wrinkles and

deep wrinkles. Creates a lifting and lling eects.

Placenta – devitalized skin, treatment of atrophic, hypertrophic and keloid scars, hair loss.

Revitalizing eect is due to increase of cell turn-over in the dermis via action of unique

combination of growth factors.

Skin (NOP and MO) – dehydrated and dry skin texture: pigmentation, dark spots and melasma.

Eectively removes pigmentations via modulation of melanocytic activity. Gives a youthful

vibrant appearance to the skin.

SPMC (Skin, Placenta, Mesenchyme, Collagen) – prevention of skin aging, wrinkles and other

signs of skin aging, sagging and loose skin, pale skin.

SCE (Skin, Collagen, Elastin) – devitalized and sagging skin, dull – looking skin; skin after the

mechanical or chemical peel or laser resurfacing and recovery after these procedures.

SPMCE (MO and NOP) – a complete multifactorial biological natural rejuvenation of skin.

Combines benecial eects of all other Changes in skin collagen types I, III, and VII and newly

synthesized collagen in the observed cohortproducts. A perfect product for the wholesome

facial revitalization.

How Does a Treatment Work?

Aesthetic biomolecular treatment is a non-surgical, warranting minimal recovery time, ensuring

prompt results and eective to cause one or more eects:

- normalization of skin color;

- decreasing production of melanin;

- increasing skin water content and hydration;

- normalization of cellular metabolism;

- improving adult stem cell proliferation;

- increasing collagen, elastin production;

- stimulation of angiogenesis;

- restoration of hair cycle and follicular development;

- prevention of apoptosis;

- increasing cell proliferation.

Application

Mesotherapy: intradermal injections according to the protocol.

Topical: application with the dermaroller or topical application twice a day on cleansed face,

neck and/or aected area (if applied after facial treatment or dermabrasion the ecacy is higher)

Evaluation of outcomes after mesotherapy with SPMCE based on the 5-point scale (3

months post-treatment (Application of Cell Extracts from Skin, Placenta, Mesenchyme

with Collagen and Elastin in Aesthetic Dermatology and Skin Revitalization: Evaluation

of Outcomes in Cohort Study. American Journal Adv Drug Deliv; 2016: 4(5); 69-77.).

35.5

37.75

34.75

34.5

25.5

26.25

42.75

27.5

32.75

27.5

32.75

43.5

28.5

30.5

Changes in skin hydration, elasticity and melanin levels in observed patients before,

during and after the mesotherapy with SPMCE

With the pioneering invention of modern Swiss ultraltration technology NOP products are

now safe to be taken sublingually, applied topically, in form of injections or administered

parenterally by physicians as an individualized organotherapy or as an aesthetic cosmetic

application. Depending on the skin problem, the doctor will select the most suitable product

among the NOP range to meet the patients’s needs and expectations.

Are the injections painful?

The injections are done with specic Nano needles and are basically pain free. In the case of

patient’s high sensitivity an anaesthetic cream is applied before the procedure.

Benets

NOP’s and MO’s organ specic components eectively target problem areas due to its biological

nature. Nourish, repair and regenerate matched molecules within the skin, and revitalize it.

Based on the multinational clinical trial evaluating the ecacy of SPMCE, the following

observations were made: “Evaluators have observed improvements in skin radiance and skin

brightness in all volunteers. The parameters reecting the skin brightness has shown gradual

improvement since third week of the study. The spectrophotometric analysis has shown

signicant reduction of skin redness and pigmentations. Most dramatic changes in terms of

decreased wrinkle height and maximum wrinkle depth were observed in periorbital (“crow’s

feet”) and perioral areas. Total wrinkle height was decreased by 27.4% by the end of the

treatment protocol, 25.1% one month post-treatment and 21.5% - 3 months post-treatment.

The maximum wrinkle depth was decrease by 20.9% by the end of the treatment at 12th week,

by 17.8% - one month post-treatment, and 15.6% - 3 months post-treatment”

(Application of Cell Extracts from Skin, Placenta, Mesenchyme with Collagen and Elastin in Aesthetic Dermatology and Skin Revitalization:

Evaluation of Outcomes in Cohort Study. American Journal Adv Drug Deliv; 2016: 4(5); 69-77).

Before After 21 days*

After 2 weeks*After 1 week*Before

35-year female with keloid scar on chest (thermal burn with hot water)

Products used: NOP Skin and NOP Placenta

22-year female with burn scar on the face after an accident.

Products used: NOP Skin and NOP Placenta

Safety and comfort

Dramatic improvements of skin and incredible

restorative powers of NOP and MO SPMCE peptides are

best observed from ‘before and after’ photos.

Changes in skin collagen types I, III, and VII and newly synthesized collagen in the observed cohort

Outstanding quality for lasting eects

In majority of patients had improvements in skin hydration and elasticity that were observed

after rst month of treatment. During the second and third months further improvements were

less prominent, however the eects gained in the initial stages of treatment demonstrated

high stability and sustained even 3 months after the last mesotherapy session.

SPMCE mesotherapy formula is capable of providing a signicant restoration of extracellular

matrix and may dramatically improve skin elasticity.

As the main purpose of mesotherapy is revitalization and maintenance of youthful skin, it

is totally achievable with successful SPMCE formula that is able to enhance cell activity

and increase dermal cell turnover, as well as promote synthesis of collagen and elastin. The

conducted study suggests that SPMCE can achieve a physiological restoration of optimal

environment in the treated tissues.

Tried and Tested

For years, NOP is known for its amazing rejuvenative properties and has brought visible

transformation and condence to users worldwide. See the results of NOP’s skin restorative

powers in these before and after photos (copyright).

Before and after the course of mesotherapy

Products used: NOP Spmce

Before and after the course of mesotherapy

Products used: MO Spmce

Nano Organo Peptides

Mito Organelles

Due to higher concentration of peptides in the MF+ MO™ SPMCE

compared to NOP/EUF, as well as molecular weight of the peptides in

the MF+ MO™ being slightly higher than in EUF/Nano peptides, it is

recommended to use a smaller quantity of the product. The technique

of intradermal injection and the volume of the injected product

are essentially dierent from the ones using llers or other known

compositions containing vitamins or hyaluronic acid. Mesotherapy with

MF+ MO™ SPMCE is the mesotherapy-as-it-is: “a little volume, a few

times, and in the right place”.

Ecacy

Results of biomolecular facial revitalization with either Nano or Mito peptides can often be

noticed after second or third sessions, which is about 2 to 3 weeks after starting the treatment

depending on metabolism and body type of the patient.

Available clinical and histochemical data proves MF+ MO™ SPMCE capacity to promote

biosynthesis of new collagen and pep elastin bers. Even after the rst month of treatment

skin looks younger and more vibrant.

The main benets of the biomolecular products is its natural physiological mechanism of

action, which does not involve administration of the llers or foreign bodies into the tissues,

and long lasting natural biological revitalizing eect. Absence of allergic reactions in the

observed users supports safety of the MF+ peptides in the aesthetic practice.

Usually one vial is enough for the entire session of facial mesotherapy and the frequency

should not be more than ones per week. Tiny amounts of the product should be applied

proportionally in the areas of concern. If some swelling is noted after repeated sessions it is

advisable to continue treatment with EUF/NOP with the similar content.

How Should NOP and MO products be stored?

NOP products have a shelf- life of 6 years, if kept in a refrigerator at optimum temperature

between +2°C and +16 °C (not frozen) and fully protected from direct sunlight.

When kept in normal room temperature, NOP products have a shelf-life of 3 months.